The Connexin46 Mutant, Cx46T19M, Causes Loss of Gap Junction Function and Alters Hemi-channel Gating

An N-terminal mutant of connexin46 (T19M) alters a highly conserved threonine and has been linked to autosomal dominant cataracts. To study the cellular and functional consequences of substitution of this amino acid, T19M was expressed in Xenopus oocytes and in HeLa cells. Unlike wild-type Cx46, T19...

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Detalles Bibliográficos
Autores principales: Tong, Jun-Jie, Minogue, Peter J., Kobeszko, Matthew, Beyer, Eric C., Berthoud, Viviana M., Ebihara, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300453/
https://www.ncbi.nlm.nih.gov/pubmed/25404239
http://dx.doi.org/10.1007/s00232-014-9752-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300453/
https://www.ncbi.nlm.nih.gov/pubmed/25404239
http://dx.doi.org/10.1007/s00232-014-9752-y

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