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Specific insulin/IGF1 hybrid receptor activation assay reveals IGF1 as a more potent ligand than insulin
This novel method enables specific measurement of the activation of hybrid receptors formed between the Insulin Receptor (IR) and the Insulin-like Growth Factor 1 Receptor (IGF1R). These hybrid receptors are present in tissues and cell lines expressing both IR and IGF1R. It is therefore challenging...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300458/ https://www.ncbi.nlm.nih.gov/pubmed/25604425 http://dx.doi.org/10.1038/srep07911 |