Cargando…

DEK is a potential marker for aggressive phenotype and irinotecan-based therapy response in metastatic colorectal cancer

BACKGROUND: DEK is a transcription factor involved in stabilization of heterochromatin and cruciform structures. It plays an important role in development and progression of different types of cancer. This study aims to analyze the role of DEK in metastatic colorectal cancer. METHODS: Baseline DEK e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martinez-Useros, Javier, Rodriguez-Remirez, Maria, Borrero-Palacios, Aurea, Moreno, Irene, Cebrian, Arancha, Gomez del Pulgar, Teresa, del Puerto-Nevado, Laura, Vega-Bravo, Ricardo, Puime-Otin, Alberto, Perez, Nuria, Zazo, Sandra, Senin, Clara, Fernandez-Aceñero, Maria J, Soengas, Maria S, Rojo, Federico, Garcia-Foncillas, Jesus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300837/ https://www.ncbi.nlm.nih.gov/pubmed/25515240 http://dx.doi.org/10.1186/1471-2407-14-965

Ejemplares similares

The potential predictive value of DEK expression for neoadjuvant chemoradiotherapy response in locally advanced rectal cancer
por: Martinez-Useros, J., et al.
Publicado: (2018)

UNR/CDSE1 expression as prognosis biomarker in resectable pancreatic ductal adenocarcinoma patients: A proof-of-concept
por: Martinez-Useros, Javier, et al.
Publicado: (2017)

Focal adhesion kinase: predictor of tumour response and risk factor for recurrence after neoadjuvant chemoradiation in rectal cancer
por: Gómez del Pulgar, Teresa, et al.
Publicado: (2016)

Predictive value of vrk 1 and 2 for rectal adenocarcinoma response to neoadjuvant chemoradiation therapy: a retrospective observational cohort study
por: del Puerto-Nevado, Laura, et al.
Publicado: (2016)

Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer
por: Aguilera, Oscar, et al.
Publicado: (2016)

Identification of Poor-outcome Biliopancreatic Carcinoma Patients With Two-marker Signature Based on ATF6α and p-p38 “STARD Compliant”
por: Martinez-Useros, J., et al.
Publicado: (2015)

UNR/CSDE1 Expression Is Critical to Maintain Invasive Phenotype of Colorectal Cancer through Regulation of c-MYC and Epithelial-to-Mesenchymal Transition
por: Martinez-Useros, Javier, et al.
Publicado: (2019)

Combination of KIR2DS4 and FcγRIIa polymorphisms predicts the response to cetuximab in KRAS mutant metastatic colorectal cancer
por: Borrero-Palacios, A., et al.
Publicado: (2019)

Author Correction: Combination of KIR2DS4 and FcγRIIa polymorphisms predicts the response to cetuximab in KRAS mutant metastatic colorectal cancer
por: Borrero-Palacios, A., et al.
Publicado: (2019)

Active angiogenesis in metastatic renal cell carcinoma predicts clinical benefit to sunitinib-based therapy
por: del Puerto-Nevado, L, et al.
Publicado: (2014)

Ras Family of Small GTPases in CRC: New Perspectives for Overcoming Drug Resistance
por: Rio-Vilariño, Anxo, et al.
Publicado: (2021)

Improving selection of patients with metastatic colorectal cancer to benefit from cetuximab based on KIR genotypes
por: Manzanares-Martin, Barbara, et al.
Publicado: (2021)

Phosphorylated protein phosphatase 2A determines poor outcome in patients with metastatic colorectal cancer
por: Cristóbal, I, et al.
Publicado: (2014)

Vitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxylic acid (TCA) cycle in hypoxic KRAS mutant colon cancer
por: Cenigaonandia-Campillo, Aiora, et al.
Publicado: (2021)

Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer
por: Aguilera, Óscar, et al.
Publicado: (2015)

The SAF-box domain of chromatin protein DEK
por: Böhm, Friederike, et al.
Publicado: (2005)

A DEK domain-containing protein GhDEK2D mediated Gossypium hirsutum enhanced resistance to Verticillium dahliae
por: Zhou, Jinglong, et al.
Publicado: (2022)

The role of DEK protein in hepatocellular carcinoma for progression and prognosis
por: Lin, Li-juan, et al.
Publicado: (2013)

Dissecting the Potential Interplay of DEK Functions in Inflammation and Cancer
por: Pease, Nicholas A., et al.
Publicado: (2015)

The DEK Oncoprotein Functions in Ovarian Cancer Growth and Survival()
por: Hacker, Kari E, et al.
Publicado: (2018)

DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis
por: Mor-Vaknin, Nirit, et al.
Publicado: (2017)

DEK is required for homologous recombination repair of DNA breaks
por: Smith, Eric A., et al.
Publicado: (2017)

Role of the DEK oncogene in the development of squamous cell carcinoma
por: Ishida, Kazuhisa, et al.
Publicado: (2020)

DLL3 Is a Prognostic and Potentially Predictive Biomarker for Immunotherapy Linked to PD/PD-L Axis and NOTCH1 in Pancreatic Cancer
por: Lacalle-Gonzalez, Carlos, et al.
Publicado: (2023)

Functional PTGS2 polymorphism-based models as novel predictive markers in metastatic renal cell carcinoma patients receiving first-line sunitinib
por: Cebrián, Arancha, et al.
Publicado: (2017)

Colon cancer modulation by a diabetic environment: A single institutional experience
por: Prieto, Isabel, et al.
Publicado: (2017)

Combined 5-FU and ChoKα Inhibitors as a New Alternative Therapy of Colorectal Cancer: Evidence in Human Tumor-Derived Cell Lines and Mouse Xenografts
por: de la Cueva, Ana, et al.
Publicado: (2013)

The Prognosis Value of PIWIL1 and PIWIL2 Expression in Pancreatic Cancer
por: Li, Weiyao, et al.
Publicado: (2019)

Oncoprotein DEK as a tissue and urinary biomarker for bladder cancer
por: Datta, Antara, et al.
Publicado: (2011)

High expression of DEK predicts poor prognosis of gastric adenocarcinoma
por: Piao, Junjie, et al.
Publicado: (2014)

Characterization of Enlarged Kidneys and Their Potential for Inducing Diabetes in DEK Rats
por: Domon, Ayaka, et al.
Publicado: (2021)

Patient Characteristics Associated with Growth of Patient-Derived Tumor Implants in Mice (Patient-Derived Xenografts)
por: Hernández Guerrero, Tatiana, et al.
Publicado: (2023)

Obesity and colorectal cancer: molecular features of adipose tissue
por: Martinez-Useros, Javier, et al.
Publicado: (2016)

The Role of BRCA2 Mutation Status as Diagnostic, Predictive, and Prognosis Biomarker for Pancreatic Cancer
por: Martinez-Useros, Javier, et al.
Publicado: (2016)

Can Molecular Biomarkers Change the Paradigm of Pancreatic Cancer Prognosis?
por: Martinez-Useros, Javier, et al.
Publicado: (2016)

The human DEK oncogene regulates DNA damage response signaling and repair
por: Kavanaugh, Gina M., et al.
Publicado: (2011)

Mechanisms Underlying Cancer Growth and Apoptosis by DEK Overexpression in Colorectal Cancer
por: Lin, Lijuan, et al.
Publicado: (2014)

DEK over expression as an independent biomarker for poor prognosis in colorectal cancer
por: Lin, Lijuan, et al.
Publicado: (2013)

Identification of DEK as a potential therapeutic target for neuroendocrine prostate cancer
por: Lin, Dong, et al.
Publicado: (2014)

Critical role of DEK and its regulation in tumorigenesis and metastasis of hepatocellular carcinoma
por: Yu, Le, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_sifa9j5idifvgsji18723kkuju