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Inactivation of Multiple Bacterial Histidine Kinases by Targeting the ATP-Binding Domain

[Image: see text] Antibacterial agents that exploit new targets will be required to combat the perpetual rise of bacterial resistance to current antibiotics. We are exploring the inhibition of histidine kinases, constituents of two-component systems. Two-component systems are the primary signaling p...

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Detalles Bibliográficos
Autores principales: Wilke, Kaelyn E., Francis, Samson, Carlson, Erin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301073/
https://www.ncbi.nlm.nih.gov/pubmed/25531939
http://dx.doi.org/10.1021/cb5008019