JF-305, a pancreatic cancer cell line is highly sensitive to the PARP inhibitor olaparib

Poly(ADP-ribose) polymerase-1 (PARP-1) is a DNA nick sensor involved in the base excision repair (BER) pathway. Olaparib, a PARP inhibitor, has demonstrated antitumor activity in homologous recombination (HR)-deficient cancers. To extend this specific therapy to other types of carcinomas, a panel of...

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Detalles Bibliográficos
Autores principales: YANG, XUELI, NDAWULA, CHARLES, ZHOU, HAIYAN, GONG, XIAOHAI, JIN, JIAN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301471/
https://www.ncbi.nlm.nih.gov/pubmed/25621047
http://dx.doi.org/10.3892/ol.2014.2762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301471/
https://www.ncbi.nlm.nih.gov/pubmed/25621047
http://dx.doi.org/10.3892/ol.2014.2762

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