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Mechanisms of methotrexate resistance in osteosarcoma cell lines and strategies for overcoming this resistance
The aim of the present study was to investigate the underlying mechanisms of methotrexate (MTX) resistance in the human osteosarcoma cell line, Saos-2/MTX4.4, and to evaluate various methods of overcoming the resistance to this chemotherapeutic agent. MMT assays were performed to determine the resis...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
D.A. Spandidos
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301490/ https://www.ncbi.nlm.nih.gov/pubmed/25621072 http://dx.doi.org/10.3892/ol.2014.2773 |