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Mechanisms of methotrexate resistance in osteosarcoma cell lines and strategies for overcoming this resistance

The aim of the present study was to investigate the underlying mechanisms of methotrexate (MTX) resistance in the human osteosarcoma cell line, Saos-2/MTX4.4, and to evaluate various methods of overcoming the resistance to this chemotherapeutic agent. MMT assays were performed to determine the resis...

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Detalles Bibliográficos
Autores principales:	WANG, JIANJUN, LI, GUOJUN
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301490/ https://www.ncbi.nlm.nih.gov/pubmed/25621072 http://dx.doi.org/10.3892/ol.2014.2773

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