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3-Bromopyruvate inhibits human gastric cancer tumor growth in nude mice via the inhibition of glycolysis

Tumor cells primarily depend upon glycolysis in order to gain energy. Therefore, the inhibition of glycolysis may inhibit tumor growth. Our previous study demonstrated that 3-bromopyruvate (3-BrPA) inhibited gastric cancer cell proliferation in vitro. However, the ability of 3-BrPA to suppress tumor...

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Autores principales: XIAN, SHU-LIN, CAO, WEI, ZHANG, XIAO-DONG, LU, YUN-FEI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301496/
https://www.ncbi.nlm.nih.gov/pubmed/25621044
http://dx.doi.org/10.3892/ol.2014.2779
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author XIAN, SHU-LIN
CAO, WEI
ZHANG, XIAO-DONG
LU, YUN-FEI
author_facet XIAN, SHU-LIN
CAO, WEI
ZHANG, XIAO-DONG
LU, YUN-FEI
author_sort XIAN, SHU-LIN
collection PubMed
description Tumor cells primarily depend upon glycolysis in order to gain energy. Therefore, the inhibition of glycolysis may inhibit tumor growth. Our previous study demonstrated that 3-bromopyruvate (3-BrPA) inhibited gastric cancer cell proliferation in vitro. However, the ability of 3-BrPA to suppress tumor growth in vivo, and its underlying mechanism, have yet to be elucidated. The aim of the present study was to investigate the inhibitory effect of 3-BrPA in an animal model of gastric cancer. It was identified that 3-BrPA exhibited strong inhibitory effects upon xenograft tumor growth in nude mice. In addition, the antitumor function of 3-BrPA exhibited a dose-effect association, which was similar to that of the chemotherapeutic agent, 5-fluorouracil. Furthermore, 3-BrPA exhibited low toxicity in the blood, liver and kidneys of the nude mice. The present study hypothesized that the inhibitory effect of 3-BrPA is achieved through the inhibition of hexokinase activity, which leads to the downregulation of B-cell lymphoma 2 (Bcl-2) expression, the upregulation of Bcl-2-associated X protein expression and the subsequent activation of caspase-3. These data suggest that 3-BrPA may be a novel therapy for the treatment of gastric cancer.
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spelling pubmed-43014962015-01-23 3-Bromopyruvate inhibits human gastric cancer tumor growth in nude mice via the inhibition of glycolysis XIAN, SHU-LIN CAO, WEI ZHANG, XIAO-DONG LU, YUN-FEI Oncol Lett Articles Tumor cells primarily depend upon glycolysis in order to gain energy. Therefore, the inhibition of glycolysis may inhibit tumor growth. Our previous study demonstrated that 3-bromopyruvate (3-BrPA) inhibited gastric cancer cell proliferation in vitro. However, the ability of 3-BrPA to suppress tumor growth in vivo, and its underlying mechanism, have yet to be elucidated. The aim of the present study was to investigate the inhibitory effect of 3-BrPA in an animal model of gastric cancer. It was identified that 3-BrPA exhibited strong inhibitory effects upon xenograft tumor growth in nude mice. In addition, the antitumor function of 3-BrPA exhibited a dose-effect association, which was similar to that of the chemotherapeutic agent, 5-fluorouracil. Furthermore, 3-BrPA exhibited low toxicity in the blood, liver and kidneys of the nude mice. The present study hypothesized that the inhibitory effect of 3-BrPA is achieved through the inhibition of hexokinase activity, which leads to the downregulation of B-cell lymphoma 2 (Bcl-2) expression, the upregulation of Bcl-2-associated X protein expression and the subsequent activation of caspase-3. These data suggest that 3-BrPA may be a novel therapy for the treatment of gastric cancer. D.A. Spandidos 2015-02 2014-12-08 /pmc/articles/PMC4301496/ /pubmed/25621044 http://dx.doi.org/10.3892/ol.2014.2779 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
XIAN, SHU-LIN
CAO, WEI
ZHANG, XIAO-DONG
LU, YUN-FEI
3-Bromopyruvate inhibits human gastric cancer tumor growth in nude mice via the inhibition of glycolysis
title 3-Bromopyruvate inhibits human gastric cancer tumor growth in nude mice via the inhibition of glycolysis
title_full 3-Bromopyruvate inhibits human gastric cancer tumor growth in nude mice via the inhibition of glycolysis
title_fullStr 3-Bromopyruvate inhibits human gastric cancer tumor growth in nude mice via the inhibition of glycolysis
title_full_unstemmed 3-Bromopyruvate inhibits human gastric cancer tumor growth in nude mice via the inhibition of glycolysis
title_short 3-Bromopyruvate inhibits human gastric cancer tumor growth in nude mice via the inhibition of glycolysis
title_sort 3-bromopyruvate inhibits human gastric cancer tumor growth in nude mice via the inhibition of glycolysis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301496/
https://www.ncbi.nlm.nih.gov/pubmed/25621044
http://dx.doi.org/10.3892/ol.2014.2779
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