Isoproterenol Acts as a Biased Agonist of the Alpha-1A-Adrenoceptor that Selectively Activates the MAPK/ERK Pathway

The α(1A)-AR is thought to couple predominantly to the Gα(q)/PLC pathway and lead to phosphoinositide hydrolysis and calcium mobilization, although certain agonists acting at this receptor have been reported to trigger activation of arachidonic acid formation and MAPK pathways. For several G protein...

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Detalles Bibliográficos
Autores principales: Copik, Alicja. J., Baldys, Aleksander, Nguyen, Khanh, Sahdeo, Sunil, Ho, Hoangdung, Kosaka, Alan, Dietrich, Paul J., Fitch, Bill, Raymond, John R., Ford, Anthony P. D. W., Button, Donald, Milla, Marcos E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301629/
https://www.ncbi.nlm.nih.gov/pubmed/25606852
http://dx.doi.org/10.1371/journal.pone.0115701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301629/
https://www.ncbi.nlm.nih.gov/pubmed/25606852
http://dx.doi.org/10.1371/journal.pone.0115701

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