Systemic Expression of Kaposi Sarcoma Herpesvirus (KSHV) Vflip in Endothelial Cells Leads to a Profound Proinflammatory Phenotype and Myeloid Lineage Remodeling In Vivo

KSHV is the causative agent of Kaposi sarcoma (KS), a spindle-shaped endothelial cell neoplasm accompanied by an inflammatory infiltrate. To evaluate the role of KSHV vFLIP in the pathogenesis of KS, we constructed mice with inducible expression of vFLIP in endothelial cells. Abnormal cells with end...

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Detalles Bibliográficos
Autores principales: Ballon, Gianna, Akar, Gunkut, Cesarman, Ethel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301867/
https://www.ncbi.nlm.nih.gov/pubmed/25607954
http://dx.doi.org/10.1371/journal.ppat.1004581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301867/
https://www.ncbi.nlm.nih.gov/pubmed/25607954
http://dx.doi.org/10.1371/journal.ppat.1004581

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