Helical Defects in MicroRNA Influence Protein Binding by TAR RNA Binding Protein

BACKGROUND: MicroRNAs (miRNAs) are critical post-transcriptional regulators of gene expression. Their precursors have a globally A-form helical geometry, which prevents most proteins from identifying their nucleotide sequence. This suggests the hypothesis that local structural features (e.g., bulges...

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Detalles Bibliográficos
Autores principales: Acevedo, Roderico, Orench-Rivera, Nichole, Quarles, Kaycee A., Showalter, Scott A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301919/
https://www.ncbi.nlm.nih.gov/pubmed/25608000
http://dx.doi.org/10.1371/journal.pone.0116749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301919/
https://www.ncbi.nlm.nih.gov/pubmed/25608000
http://dx.doi.org/10.1371/journal.pone.0116749

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