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Helical Defects in MicroRNA Influence Protein Binding by TAR RNA Binding Protein
BACKGROUND: MicroRNAs (miRNAs) are critical post-transcriptional regulators of gene expression. Their precursors have a globally A-form helical geometry, which prevents most proteins from identifying their nucleotide sequence. This suggests the hypothesis that local structural features (e.g., bulges...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301919/ https://www.ncbi.nlm.nih.gov/pubmed/25608000 http://dx.doi.org/10.1371/journal.pone.0116749 |