Activation of toll like receptor 4 attenuates GABA synthesis and postsynaptic GABA receptor activities in the spinal dorsal horn via releasing interleukin-1 beta

Toll like receptor 4 (TLR4) is an innate immune pattern recognition receptor, expressed predominantly on microglia in the CNS. Activation of spinal TLR4 plays a critical role in the genesis of pathological pain induced by nerve injury, bone cancer, and tissue inflammation. Currently, it remains unkn...

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Detalles Bibliográficos
Autores principales: Yan, Xisheng, Jiang, Enshe, Weng, Han-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302431/
https://www.ncbi.nlm.nih.gov/pubmed/25571780
http://dx.doi.org/10.1186/s12974-014-0222-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302431/
https://www.ncbi.nlm.nih.gov/pubmed/25571780
http://dx.doi.org/10.1186/s12974-014-0222-3

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