Sequential combination therapy with flavopiridol and autocatalytic caspase-3 driven by amplified hTERT promoter synergistically suppresses human ovarian carcinoma growth in vitro and in mice

BACKGROUND: Induction of cell apoptosis and regulation of cell cycle are very attractive for treatments of tumors including ovarian carcinoma. Flavopiridol is a potent small molecular cyclin-dependent kinase(cdk) inhibitor, but its antitumor efficacy is not satisfied yet. Caspase-3 play a major role...

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Detalles Bibliográficos
Autores principales: Song, Yue, Xin, Xing, Zhai, Xingyue, Xia, Zhijun, Shen, Keng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302516/
https://www.ncbi.nlm.nih.gov/pubmed/25528169
http://dx.doi.org/10.1186/s13048-014-0121-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302516/
https://www.ncbi.nlm.nih.gov/pubmed/25528169
http://dx.doi.org/10.1186/s13048-014-0121-3

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