Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism

BACKGROUND: We have uncovered a caspase-dependent (caspase-8/caspase-3/7) signaling governing microglia activation and associated neurotoxicity. Importantly, a profuse non-nuclear activation of cleaved caspases 8 and 3 was found in reactive microglia in the ventral mesencephalon from subjects with P...

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Detalles Bibliográficos
Autores principales: Viceconte, Nikenza, Burguillos, Miguel A, Herrera, Antonio J, De Pablos, Rocío M, Joseph, Bertrand, Venero, José L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302615/
https://www.ncbi.nlm.nih.gov/pubmed/25586882
http://dx.doi.org/10.1186/s12974-014-0228-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302615/
https://www.ncbi.nlm.nih.gov/pubmed/25586882
http://dx.doi.org/10.1186/s12974-014-0228-x

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