Recurring DNA copy number gain at chromosome 9p13 plays a role in the activation of multiple candidate oncogenes in progressing oral premalignant lesions

Genomic alteration at chromosome 9p has been previously reported as a frequent and critical event in oral premalignancy. While this alteration is typically reported as a loss driven by selection for CDKN2A deactivation (at 9p21.3), we detect a recurrent DNA copy number gain of ∼2.49 Mbp at chromosom...

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Detalles Bibliográficos
Autores principales: Towle, Rebecca, Tsui, Ivy F L, Zhu, Yuqi, MacLellan, Sara, Poh, Catherine F, Garnis, Cathie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302668/
https://www.ncbi.nlm.nih.gov/pubmed/25060540
http://dx.doi.org/10.1002/cam4.307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302668/
https://www.ncbi.nlm.nih.gov/pubmed/25060540
http://dx.doi.org/10.1002/cam4.307

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