IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T cell-mediated colitis

Polymorphisms attenuating IL-10 signaling confer genetic risk for inflammatory bowel disease. Yet how IL-10 prevents mucosal autoinflammation is incompletely understood. We demonstrate using lineage-specific deletions of IL-10Rα that IL-10 acts primarily through macrophages to limit colitis. Colitis...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Bofeng, Gurung, Prajwal, Subbarao Malireddi, R. K., Vogel, Peter, Kanneganti, Thirumala-Devi, Geiger, Terrence L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302761/
https://www.ncbi.nlm.nih.gov/pubmed/25607885
http://dx.doi.org/10.1038/ncomms7131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302761/
https://www.ncbi.nlm.nih.gov/pubmed/25607885
http://dx.doi.org/10.1038/ncomms7131

Ejemplares similares