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IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T cell-mediated colitis
Polymorphisms attenuating IL-10 signaling confer genetic risk for inflammatory bowel disease. Yet how IL-10 prevents mucosal autoinflammation is incompletely understood. We demonstrate using lineage-specific deletions of IL-10Rα that IL-10 acts primarily through macrophages to limit colitis. Colitis...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302761/ https://www.ncbi.nlm.nih.gov/pubmed/25607885 http://dx.doi.org/10.1038/ncomms7131 |