Repressive mutations restore function-loss caused by the disruption of trimerization in Escherichia coli multidrug transporter AcrB

AcrAB-TolC and their homologs are major multidrug efflux systems in Gram-negative bacteria. The inner membrane component AcrB functions as a trimer. Replacement of Pro223 by Gly in AcrB decreases the trimer stability and drastically reduces the drug efflux activity. The goal of this study is to iden...

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Detalles Bibliográficos
Autores principales: Wang, Zhaoshuai, Zhong, Meng, Lu, Wei, Chai, Qian, Wei, Yinan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303003/
https://www.ncbi.nlm.nih.gov/pubmed/25657644
http://dx.doi.org/10.3389/fmicb.2015.00004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303003/
https://www.ncbi.nlm.nih.gov/pubmed/25657644
http://dx.doi.org/10.3389/fmicb.2015.00004

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