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Repressive mutations restore function-loss caused by the disruption of trimerization in Escherichia coli multidrug transporter AcrB
AcrAB-TolC and their homologs are major multidrug efflux systems in Gram-negative bacteria. The inner membrane component AcrB functions as a trimer. Replacement of Pro223 by Gly in AcrB decreases the trimer stability and drastically reduces the drug efflux activity. The goal of this study is to iden...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303003/ https://www.ncbi.nlm.nih.gov/pubmed/25657644 http://dx.doi.org/10.3389/fmicb.2015.00004 |