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Emerging Models for the Molecular Basis of Mammalian Circadian Timing
[Image: see text] Mammalian circadian timekeeping arises from a transcription-based feedback loop driven by a set of dedicated clock proteins. At its core, the heterodimeric transcription factor CLOCK:BMAL1 activates expression of Period, Cryptochrome, and Rev-Erb genes, which feed back to repress t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical Society
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303291/ https://www.ncbi.nlm.nih.gov/pubmed/25303119 http://dx.doi.org/10.1021/bi500731f |