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Kinetic and Structural Requirements for Carbapenemase Activity in GES-Type β-Lactamases
[Image: see text] Carbapenems are the last resort antibiotics for treatment of life-threatening infections. The GES β-lactamases are important contributors to carbapenem resistance in clinical bacterial pathogens. A single amino acid difference at position 170 of the GES-1, GES-2, and GES-5 enzymes...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303295/ https://www.ncbi.nlm.nih.gov/pubmed/25485972 http://dx.doi.org/10.1021/bi501052t |