Cargando…

Kinetic and Structural Requirements for Carbapenemase Activity in GES-Type β-Lactamases

[Image: see text] Carbapenems are the last resort antibiotics for treatment of life-threatening infections. The GES β-lactamases are important contributors to carbapenem resistance in clinical bacterial pathogens. A single amino acid difference at position 170 of the GES-1, GES-2, and GES-5 enzymes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stewart, Nichole K., Smith, Clyde A., Frase, Hilary, Black, D. J., Vakulenko, Sergei B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303295/ https://www.ncbi.nlm.nih.gov/pubmed/25485972 http://dx.doi.org/10.1021/bi501052t

Ejemplares similares

Class D β-lactamases do exist in Gram-positive bacteria
por: Toth, Marta, et al.
Publicado: (2015)

Intrinsic Class D β-Lactamases of Clostridium difficile
por: Toth, Marta, et al.
Publicado: (2018)

Aminoglycoside resistance profile and structural architecture of the aminoglycoside acetyltransferase AAC(6')-Im
por: Smith, Clyde A., et al.
Publicado: (2017)

C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Acinetobacter baumannii Carbapenemase OXA-23 by Impeding Deacylation
por: Stewart, Nichole K., et al.
Publicado: (2022)

Targeting the Class A Carbapenemase GES-5 via Virtual Screening
por: Klein, Raphael, et al.
Publicado: (2020)

In vitro activity of the β-lactamase inhibitor NXL104 against KPC-2 carbapenemase and Enterobacteriaceae expressing KPC carbapenemases
por: Stachyra, Thérèse, et al.
Publicado: (2009)

Extended-spectrum β-lactamase-producing and carbapenemase-producing Enterobacteriaceae
por: Wilson, Hayley, et al.
Publicado: (2018)

CRISPR-Cas13a-Based Assay for Accurate Detection of OXA-48 and GES Carbapenemases
por: Ortiz-Cartagena, Concha, et al.
Publicado: (2023)

Corrigendum: Extended-spectrum β-lactamase-producing and carbapenemase-producing Enterobacteriaceae
por: Wilson, Hayley, et al.
Publicado: (2018)

Molecular diversity of extended-spectrum β-lactamases and carbapenemases, and antimicrobial resistance
por: Sawa, Teiji, et al.
Publicado: (2020)

Emergence of β-lactamase- and carbapenemase- producing Enterobacteriaceae at integrated fish farms
por: Hamza, Dalia, et al.
Publicado: (2020)

Extensively drug-resistant (XDR) Pseudomonas aeruginosa identified in Lima, Peru co-expressing a VIM-2 metallo-β-lactamase, OXA-1 β-lactamase and GES-1 extended-spectrum β-lactamase
por: Ríos, Paul, et al.
Publicado: (2018)

A Multispecies Cluster of GES-5 Carbapenemase–Producing Enterobacterales Linked by a Geographically Disseminated Plasmid
por: Ellington, Matthew J, et al.
Publicado: (2019)

Assessing the in vivo efficacy of rational antibiotics and combinations against difficult-to-treat Pseudomonas aeruginosa producing GES β-lactamases
por: Abouelhassan, Yasmeen, et al.
Publicado: (2023)

Quantitative Insights Into β-Lactamase Inhibitor’s Contribution in the Treatment of Carbapenemase-Producing Organisms With β-Lactams
por: Feng, Yanfang, et al.
Publicado: (2021)

QM/MM Simulations Reveal the Determinants of Carbapenemase Activity in Class A β-Lactamases
por: Chudyk, Ewa I., et al.
Publicado: (2022)

Spread of GES-5 carbapenemase-producing Pseudomonas aeruginosa clinical isolates in Japan due to clonal expansion of ST235
por: Hishinuma, Tomomi, et al.
Publicado: (2018)

Prevalence of β-lactamase-encoding genes and molecular typing of Acinetobacter baumannii isolates carrying carbapenemase OXA-24 in children
por: Yousefi Nojookambari, Neda, et al.
Publicado: (2021)

Development of a Novel Loop-Mediated Isothermal Amplification Method to Detect Guiana Extended-Spectrum (GES) β-Lactamase Genes in Pseudomonas aeruginosa
por: Takano, Chika, et al.
Publicado: (2019)

Evaluation of Three Carbapenemase-Phenotypic Detection Methods and Emergence of Diverse VIM and GES Variants among Pseudomonas aeruginosa Isolates in Tunisia
por: Ferjani, Sana, et al.
Publicado: (2022)

Combined Use of the Modified Hodge Test and Carbapenemase Inhibition Test for Detection of Carbapenemase-Producing Enterobacteriaceae and Metallo-β-Lactamase-Producing Pseudomonas spp.
por: Song, Wonkeun, et al.
Publicado: (2015)

Extended Spectrum-β-Lactamase or Carbapenemase Producing Bacteria Isolated from Patients with Acute Cholangitis
por: Goo, Ja Chung, et al.
Publicado: (2012)

First Report of New Delhi Metallo-β-Lactamase Carbapenemase–Producing Acinetobacter baumannii in Peru
por: Rocha, Claudio, et al.
Publicado: (2019)

HIV Drugs Inhibit Transfer of Plasmids Carrying Extended-Spectrum β-Lactamase and Carbapenemase Genes
por: Buckner, Michelle M. C., et al.
Publicado: (2020)

Prevalence of extended-spectrum β-lactamases, AmpC, and carbapenemases in Proteus mirabilis clinical isolates
por: Shaaban, Mona, et al.
Publicado: (2022)

Prevalence and Characterization of Extended-Spectrum β-Lactamase- and Carbapenemase-Producing Enterobacterales from Tunisian Seafood
por: Sola, Mehdi, et al.
Publicado: (2022)

Prevalence of Carbapenemase and Extended-Spectrum β-Lactamase Producing Enterobacteriaceae: A Cross-Sectional Study
por: Mustafai, Muhammad Muqaddas, et al.
Publicado: (2023)

Effect of Point Defects on Electronic Structure of Monolayer GeS
por: Choi, Hyeong-Kyu, et al.
Publicado: (2021)

Prediction of the electronic structure of single-walled GeS nanotubes
por: Yu, Deyang, et al.
Publicado: (2022)

First Detection of GES-5-Producing Escherichia coli from Livestock—An Increasing Diversity of Carbapenemases Recognized from German Pig Production
por: Irrgang, Alexandra, et al.
Publicado: (2020)

Erratum: Extended Spectrum-β-Lactamase or Carbapenemase Producing Bacteria Isolated from Patients with Acute Cholangitis
por: Goo, Ja Chung, et al.
Publicado: (2012)

New Delhi metallo-β-lactamase and OXA-48 carbapenemases in Gram-negative bacilli isolates in Libya
por: Kraiem, Abdulmajeed G., et al.
Publicado: (2015)

Carriage of β-lactamase and carbapenemase-producing Enterobacteriaceae in hospitalized patients at debre tabor comprehensive specialized hospital
por: Kiros, Teklehaimanot, et al.
Publicado: (2023)

The DELPHI GES : Design Document
por: DELPHI Collaboration
Publicado: (1992)

New Delhi metallo-β-lactamase - type carbapenemases producing Escherichia coli isolates from hospitalized patients: A pilot study
por: Grover, Shyam Sunder, et al.
Publicado: (2017)

Acquired bla(VIM) and bla(GES) Carbapenemase-Encoding Genes in Pseudomonas aeruginosa: A Seven-Year Survey Highlighting an Increasing Epidemiological Threat
por: Martínez-Zavaleta, María Guadalupe, et al.
Publicado: (2023)

Activity of novel β-lactam/β-lactamase inhibitor combinations against serine carbapenemase-producing carbapenem-resistant Pseudomonas aeruginosa
por: Lee, Su Young, et al.
Publicado: (2023)

Extended-Spectrum β-Lactamases and/or Carbapenemases-Producing Enterobacteriaceae Isolated from Retail Chicken Meat in Zagazig, Egypt
por: Abdallah, H. M., et al.
Publicado: (2015)

Extended-spectrum β-lactamase and carbapenemase production among burn and non-burn clinical isolates of Klebsiella pneumoniae
por: Eftekhar, Fereshteh, et al.
Publicado: (2015)

Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases
por: Spyrakis, Francesca, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ohdis7vj8c3et1pag2l29dbkhk