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Kinetic and Structural Requirements for Carbapenemase Activity in GES-Type β-Lactamases

[Image: see text] Carbapenems are the last resort antibiotics for treatment of life-threatening infections. The GES β-lactamases are important contributors to carbapenem resistance in clinical bacterial pathogens. A single amino acid difference at position 170 of the GES-1, GES-2, and GES-5 enzymes...

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Detalles Bibliográficos
Autores principales:	Stewart, Nichole K., Smith, Clyde A., Frase, Hilary, Black, D. J., Vakulenko, Sergei B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303295/ https://www.ncbi.nlm.nih.gov/pubmed/25485972 http://dx.doi.org/10.1021/bi501052t

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