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Cooperative Stabilization of Transthyretin by Clusterin and Diflunisal

[Image: see text] The circulating protein transthyretin (TTR) can unfold, oligomerize, and form highly structured amyloid fibrils that are deposited in tissues, causing organ damage and disease. This pathogenic process is caused by a heritable TTR point mutation in cases of familial TTR-related amyl...

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Detalles Bibliográficos
Autores principales: Greene, Michael J., Klimtchuk, Elena S., Seldin, David C., Berk, John L., Connors, Lawreen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303310/
https://www.ncbi.nlm.nih.gov/pubmed/25478940
http://dx.doi.org/10.1021/bi5011249