Loss of Epithelial p53 and αv Integrin Cooperate through Akt to Induce Squamous Cell Carcinoma yet Prevent Remodeling of the Tumor Microenvironment

Most of the squamous cell carcinomas (SCCs) of the skin and head and neck contain p53 mutations. The presence of p53 mutations in premalignant lesions suggests that they represent early events during tumor progression and additional alterations may be required for SCC development. Here we show that...

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Detalles Bibliográficos
Autores principales: Savar, Aaron, Acin, Sergio, Gonzalez, Cassandra L., El-Sawy, Tarek, Mejia, Olga, Li, Zhongyou, Esmaeli, Bita, Lacy-Hulbert, Adam, El-Naggar, Adel, McCarty, Joseph H., Caulin, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303549/
https://www.ncbi.nlm.nih.gov/pubmed/24469034
http://dx.doi.org/10.1038/onc.2013.585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303549/
https://www.ncbi.nlm.nih.gov/pubmed/24469034
http://dx.doi.org/10.1038/onc.2013.585

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