Triggering Apoptotic Death of Human Epidermal Keratinocytes by Malic Acid: Involvement of Endoplasmic Reticulum Stress- and Mitochondria-Dependent Signaling Pathways

Malic acid (MA) has been commonly used in cosmetic products, but the safety reports in skin are sparse. To investigate the biological effects of MA in human skin keratinocytes, we investigated the potential cytotoxicity and apoptotic effects of MA in human keratinocyte cell lines (HaCaT). The data s...

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Detalles Bibliográficos
Autores principales: Hsiao, Yu-Ping, Lai, Wan-Wen, Wu, Shi-Bei, Tsai, Chung-Hung, Tang, Sheau-Chung, Chung, Jing-Gung, Yang, Jen-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303815/
https://www.ncbi.nlm.nih.gov/pubmed/25584429
http://dx.doi.org/10.3390/toxins7010081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303815/
https://www.ncbi.nlm.nih.gov/pubmed/25584429
http://dx.doi.org/10.3390/toxins7010081

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