Crucial role of the Rap G protein signal in Notch activation and leukemogenicity of T-cell acute lymphoblastic leukemia

The Rap G protein signal regulates Notch activation in early thymic progenitor cells, and deregulated Rap activation (Rap(high)) results in the development of Notch-dependent T-cell acute lymphoblastic leukemia (T-ALL). We demonstrate that the Rap signal is required for the proliferation and leukemo...

Descripción completa

Detalles Bibliográficos
Autores principales: Doi, Keiko, Imai, Takahiko, Kressler, Christopher, Yagita, Hideo, Agata, Yasutoshi, Vooijs, Marc, Hamazaki, Yoko, Inoue, Joe, Minato, Nagahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303867/
https://www.ncbi.nlm.nih.gov/pubmed/25613394
http://dx.doi.org/10.1038/srep07978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303867/
https://www.ncbi.nlm.nih.gov/pubmed/25613394
http://dx.doi.org/10.1038/srep07978

Ejemplares similares