Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity

Soluble amyloid β-protein (Aβ) oligomers, the main neurotoxic species, are predominantly formed from monomers through a fibril-catalyzed secondary nucleation. Herein, we virtually screened an in-house library of natural compounds and discovered brazilin as a dual functional compound in both Aβ(42) f...

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Detalles Bibliográficos
Autores principales: Du, Wen-Jie, Guo, Jing-Jing, Gao, Ming-Tao, Hu, Sheng-Quan, Dong, Xiao-Yan, Han, Yi-Fan, Liu, Fu-Feng, Jiang, Shaoyi, Sun, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303869/
https://www.ncbi.nlm.nih.gov/pubmed/25613018
http://dx.doi.org/10.1038/srep07992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303869/
https://www.ncbi.nlm.nih.gov/pubmed/25613018
http://dx.doi.org/10.1038/srep07992

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