Discovery of Highly Potent Tyrosinase Inhibitor, T1, with Significant Anti-Melanogenesis Ability by zebrafish in vivo Assay and Computational Molecular Modeling

Tyrosinase is involved in melanin biosynthesis and the abnormal accumulation of melanin pigments leading to hyperpigmentation disorders that can be treated with depigmenting agents. A natural product T1, bis(4-hydroxybenzyl)sulfide, isolated from the Chinese herbal plant, Gastrodia elata, is a stron...

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Detalles Bibliográficos
Autores principales: Chen, Wang-Chuan, Tseng, Tien-Sheng, Hsiao, Nai-Wan, Lin, Yun-Lian, Wen, Zhi-Hong, Tsai, Chin-Chuan, Lee, Yu-Ching, Lin, Hui-Hsiung, Tsai, Keng-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303873/
https://www.ncbi.nlm.nih.gov/pubmed/25613357
http://dx.doi.org/10.1038/srep07995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303873/
https://www.ncbi.nlm.nih.gov/pubmed/25613357
http://dx.doi.org/10.1038/srep07995

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