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Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia

Selective elimination of synaptic connections is a common phenomenon which occurs during both developmental and pathological conditions. Glial cells have a central role in the pruning of synapses by specifically engulfing the degenerating neurites of inappropriate connections, but its regulatory mec...

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Detalles Bibliográficos
Autores principales: Bahrini, Insaf, Song, Ji-hoon, Diez, Diego, Hanayama, Rikinari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303875/
https://www.ncbi.nlm.nih.gov/pubmed/25612542
http://dx.doi.org/10.1038/srep07989