Structural basis of RGD-hirudin binding to thrombin: Tyr(3) and five C-terminal residues are crucial for inhibiting thrombin activity

BACKGROUND: Hirudin is an anti-coagulation protein produced by the salivary glands of the medicinal leech Hirudomedicinalis. It is a powerful and specific thrombin inhibitor. The novel recombinant hirudin, RGD-hirudin, which contains an RGD motif, competitively inhibits the binding of fibrinogen to...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Yinong, Zhang, Yanling, Zhao, Bing, Xu, Qiping, Zhou, Xiushi, Song, Houyan, Yu, Min, Mo, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304120/
https://www.ncbi.nlm.nih.gov/pubmed/25526801
http://dx.doi.org/10.1186/s12900-014-0026-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304120/
https://www.ncbi.nlm.nih.gov/pubmed/25526801
http://dx.doi.org/10.1186/s12900-014-0026-9

Ejemplares similares