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Structural basis of RGD-hirudin binding to thrombin: Tyr(3) and five C-terminal residues are crucial for inhibiting thrombin activity
BACKGROUND: Hirudin is an anti-coagulation protein produced by the salivary glands of the medicinal leech Hirudomedicinalis. It is a powerful and specific thrombin inhibitor. The novel recombinant hirudin, RGD-hirudin, which contains an RGD motif, competitively inhibits the binding of fibrinogen to...
Autores principales: | Huang, Yinong, Zhang, Yanling, Zhao, Bing, Xu, Qiping, Zhou, Xiushi, Song, Houyan, Yu, Min, Mo, Wei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304120/ https://www.ncbi.nlm.nih.gov/pubmed/25526801 http://dx.doi.org/10.1186/s12900-014-0026-9 |
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