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Protein sector analysis for the clustering of disease-associated mutations

BACKGROUND: The importance of mutations in disease phenotype has been studied, with information available in databases such as OMIM. However, it remains a research challenge for the possibility of clustering amino acid residues based on an underlying interaction, such as co-evolution, to understand...

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Detalles Bibliográficos
Autores principales: Guevara-Coto, Jose, Schwartz, Charles E, Wang, Liangjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304181/
https://www.ncbi.nlm.nih.gov/pubmed/25559331
http://dx.doi.org/10.1186/1471-2164-15-S11-S4