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Selective impairment of methylation maintenance is the major cause of DNA methylation reprogramming in the early embryo
BACKGROUND: DNA methylomes are extensively reprogrammed during mouse pre-implantation and early germ cell development. The main feature of this reprogramming is a genome-wide decrease in 5-methylcytosine (5mC). Standard high-resolution single-stranded bisulfite sequencing techniques do not allow dis...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304184/ https://www.ncbi.nlm.nih.gov/pubmed/25621012 http://dx.doi.org/10.1186/1756-8935-8-1 |