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BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease
β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the β-secretase enzyme required for the production of the neurotoxic β-amyloid (Aβ) peptide that is widely considered to have a crucial early role in the etiology of Alzheimer’s disease (AD). As a result, BACE1 has emerged as a prime drug...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304279/ https://www.ncbi.nlm.nih.gov/pubmed/25621019 http://dx.doi.org/10.1186/s13195-014-0089-7 |