Function through bio-inspired, synthesis-informed design: step-economical syntheses of designed kinase inhibitors

The human kinome comprises over 500 protein kinases. When mutated or over-expressed, many play critical roles in abnormal cellular functions associated with cancer, cardiovascular disease and neurological disorders. Here we report a step-economical approach to designed kinase inhibitors inspired by...

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Detalles Bibliográficos
Autores principales: Wender, Paul A., Axtman, Alison D., Golden, Jennifer E., Kee, Jung-Min, Sirois, Lauren E., Quiroz, Ryan V., Stevens, Matthew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2014
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304288/
https://www.ncbi.nlm.nih.gov/pubmed/25632347
http://dx.doi.org/10.1039/c4qo00228h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304288/
https://www.ncbi.nlm.nih.gov/pubmed/25632347
http://dx.doi.org/10.1039/c4qo00228h

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