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Function through bio-inspired, synthesis-informed design: step-economical syntheses of designed kinase inhibitors
The human kinome comprises over 500 protein kinases. When mutated or over-expressed, many play critical roles in abnormal cellular functions associated with cancer, cardiovascular disease and neurological disorders. Here we report a step-economical approach to designed kinase inhibitors inspired by...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304288/ https://www.ncbi.nlm.nih.gov/pubmed/25632347 http://dx.doi.org/10.1039/c4qo00228h |