Cargando…
Enantioconvergent Synthesis of Functionalized γ-Butyrolactones via (3 + 2)-Annulation
[Image: see text] A dynamic kinetic resolution of β-halo α-keto esters in an asymmetric homoenolate reaction is described. A chiral N-hetereocyclic carbene catalyzes the a(3) → d(3)-umpolung addition of α,β-enals to racemic α-keto esters, forming γ-butyrolactones with three contiguous stereocenters....
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304455/ https://www.ncbi.nlm.nih.gov/pubmed/25533016 http://dx.doi.org/10.1021/ja511701j |