Cargando…
A Chemically Cross-Linked Knottin Dimer Binds Integrins with Picomolar Affinity and Inhibits Tumor Cell Migration and Proliferation
[Image: see text] Molecules that target and inhibit α(v)β(3), α(v)β(5), and α(5)β(1) integrins have generated great interest because of the role of these receptors in mediating angiogenesis and metastasis. Attempts to increase the binding affinity and hence the efficacy of integrin inhibitors by dim...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304478/ https://www.ncbi.nlm.nih.gov/pubmed/25486381 http://dx.doi.org/10.1021/ja508416e |