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Deubiquitinases and the new therapeutic opportunities offered to cancer

Deubiquitinases (DUBs) play important roles and therefore are potential drug targets in various diseases including cancer and neurodegeneration. In this review, we recapitulate structure–function studies of the most studied DUBs including USP7, USP22, CYLD, UCHL1, BAP1, A20, as well as ataxin 3 and...

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Detalles Bibliográficos
Autores principales: Pfoh, Roland, Lacdao, Ira Kay, Saridakis, Vivian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304536/
https://www.ncbi.nlm.nih.gov/pubmed/25605410
http://dx.doi.org/10.1530/ERC-14-0516