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Combining biophysical methods for the analysis of protein complex stoichiometry and affinity in SEDPHAT

Reversible macromolecular interactions are ubiquitous in signal transduction pathways, often forming dynamic multi-protein complexes with three or more components. Multivalent binding and cooperativity in these complexes are often key motifs of their biological mechanisms. Traditional solution bioph...

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Detalles Bibliográficos
Autores principales: Zhao, Huaying, Schuck, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304681/
https://www.ncbi.nlm.nih.gov/pubmed/25615855
http://dx.doi.org/10.1107/S1399004714010372