Effect of Natural and Semisynthetic Pseudoguianolides on the Stability of NF-κB:DNA Complex Studied by Agarose Gel Electrophoresis

The nuclear factor κB (NF-κB) is a promising target for drug discovery. NF-κB is a heterodimeric complex of RelA and p50 subunits that interact with the DNA, regulating the expression of several genes; its dysregulation can trigger diverse diseases including inflammation, immunodeficiency, and cance...

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Detalles Bibliográficos
Autores principales: Villagomez, Rodrigo, Hatti-Kaul, Rajni, Sterner, Olov, Almanza, Giovanna, Linares-Pastén, Javier A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304792/
https://www.ncbi.nlm.nih.gov/pubmed/25615602
http://dx.doi.org/10.1371/journal.pone.0115819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304792/
https://www.ncbi.nlm.nih.gov/pubmed/25615602
http://dx.doi.org/10.1371/journal.pone.0115819

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