Modeling functional changes to Escherichia coli thymidylate synthase upon single residue replacements: a structure-based approach

Escherichia coli thymidylate synthase (TS) is an enzyme that is indispensable to DNA synthesis and cell division, as it provides the only de novo source of dTMP by catalyzing the reductive methylation of dUMP, thus making it a key target for chemotherapeutic agents. High resolution X-ray crystallogr...

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Detalles Bibliográficos
Autor principal: Masso, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2015
Materias:
Bioinformatics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304848/
https://www.ncbi.nlm.nih.gov/pubmed/25648456
http://dx.doi.org/10.7717/peerj.721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304848/
https://www.ncbi.nlm.nih.gov/pubmed/25648456
http://dx.doi.org/10.7717/peerj.721

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