Stapled HIV-1 Peptides Recapitulate Antigenic Structures and Engage Broadly Neutralizing Antibodies

Hydrocarbon stapling can restore bioactive, α-helical structure to natural peptides, yielding research tools and prototype therapeutics to dissect and target protein interactions. Here, we explore the capacity of peptide stapling to generate high fidelity, protease-resistant mimics of antigenic stru...

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Detalles Bibliográficos
Autores principales: Bird, Gregory H., Irimia, Adriana, Ofek, Gilad, Kwong, Peter D., Wilson, Ian A., Walensky, Loren D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304871/
https://www.ncbi.nlm.nih.gov/pubmed/25420104
http://dx.doi.org/10.1038/nsmb.2922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304871/
https://www.ncbi.nlm.nih.gov/pubmed/25420104
http://dx.doi.org/10.1038/nsmb.2922

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