Sequencing of the human IG light chain loci from a hydatidiform mole BAC library reveals locus-specific signatures of genetic diversity

Germline variation at immunoglobulin (IG) loci is critical for pathogen-mediated immunity, but establishing complete haplotype sequences in these regions has been problematic because of complex sequence architecture and diploid source DNA. We sequenced BAC clones from the effectively haploid human h...

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Detalles Bibliográficos
Autores principales: Watson, C T, Steinberg, K M, Graves, T A, Warren, R L, Malig, M, Schein, J, Wilson, R K, Holt, R A, Eichler, E E, Breden, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304971/
https://www.ncbi.nlm.nih.gov/pubmed/25338678
http://dx.doi.org/10.1038/gene.2014.56

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304971/
https://www.ncbi.nlm.nih.gov/pubmed/25338678
http://dx.doi.org/10.1038/gene.2014.56

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