Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody

α(1)-Antitrypsin is primarily synthesised in the liver, circulates to the lung and protects pulmonary tissues from proteolytic damage. The Z mutant (Glu342Lys) undergoes inactivating conformational change and polymerises. Polymers are retained within the hepatocyte endoplasmic reticulum (ER) in homo...

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Detalles Bibliográficos
Autores principales: Tan, Lu, Perez, Juan, Mela, Marianna, Miranda, Elena, Burling, Keith A, Rouhani, Farshid N, DeMeo, Dawn L, Haq, Imran, Irving, James A, Ordóñez, Adriana, Dickens, Jennifer A, Brantly, Mark, Marciniak, Stefan J, Alexander, Graeme J M, Gooptu, Bibek, Lomas, David A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305080/
https://www.ncbi.nlm.nih.gov/pubmed/25462157
http://dx.doi.org/10.1016/j.biocel.2014.11.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305080/
https://www.ncbi.nlm.nih.gov/pubmed/25462157
http://dx.doi.org/10.1016/j.biocel.2014.11.005

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