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Tau aggregation and its interplay with amyloid-β

Neurofibrillary tangles and amyloid plaques constitute the hallmark brain lesions of Alzheimer’s disease (AD) patients. Tangles are composed of fibrillar aggregates of the microtubule-associated protein tau, and plaques comprise fibrillar forms of a proteolytic cleavage product, amyloid-β (Aβ). Alth...

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Detalles Bibliográficos
Autores principales: Nisbet, Rebecca M., Polanco, Juan-Carlos, Ittner, Lars M., Götz, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305093/
https://www.ncbi.nlm.nih.gov/pubmed/25492702
http://dx.doi.org/10.1007/s00401-014-1371-2