Nijmegen breakage syndrome fibroblasts expressing the C-terminal truncated NBN(p70) protein undergo p38/MK2-dependent premature senescence

Fibroblasts from the progeroid Nijmegen breakage syndrome that express a truncated version of the nibrin protein (NBN(p70)) undergo premature senescence and have an enlarged morphology with high levels of senescence-associated β-galactosidase, although they do not have F-actin stress fibres. Growth...

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Detalles Bibliográficos
Autores principales: Davis, Terence, Tivey, Hannah S. E., Brook, Amy J. C., Kipling, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305097/
https://www.ncbi.nlm.nih.gov/pubmed/25214013
http://dx.doi.org/10.1007/s10522-014-9530-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305097/
https://www.ncbi.nlm.nih.gov/pubmed/25214013
http://dx.doi.org/10.1007/s10522-014-9530-3

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