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Integrin α(IIb)β(3) Transmembrane Domain Separation Mediates Bi-Directional Signaling across the Plasma Membrane
Integrins play an essential role in hemostasis, thrombosis, and cell migration, and they transmit bidirectional signals. Transmembrane/cytoplasmic domains are hypothesized to associate in the resting integrins; whereas, ligand binding and intracellular activating signals induce transmembrane domain...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305291/ https://www.ncbi.nlm.nih.gov/pubmed/25617834 http://dx.doi.org/10.1371/journal.pone.0116208 |