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RAD51 and MRE11 dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks

In higher eukaryotes the dynamics of replisome components during fork collapse and restart are poorly understood. Here, we reconstituted replication fork collapse and restart by inducing single-strand DNA (ssDNA) lesions that create a double-strand break (DSB) in one of the replicated sister chromat...

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Detalles Bibliográficos
Autores principales: Hashimoto, Yoshitami, Puddu, Fabio, Costanzo, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306020/
https://www.ncbi.nlm.nih.gov/pubmed/22139015
http://dx.doi.org/10.1038/nsmb.2177